Who we are

Welcome to Marcelo Nollmann's research group at the Center for Structural Biochemistry of the CNRS/INSERM
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​We develop single-molecule and advanced microscopy methodologies to understand the mechanisms underlying DNA organization in multi-cellular organisms. 

News
Feb'19: congratulations to the team for the Hi-M paper being accepted in Mol Cell !
​Jan'18: physics to understand living systems: interview by the Bettencourt Schueller Fondation.  
Nov'17: we were awarded the Bettencourt-Schueller 'Coup d'Elan 2017' prize !
Sept'17: Diego, Andres and Mariya had their paper accepted in Nature Communications!
Sep '17: Our ERC consolidator grant started!
Aug'17: Desiree's and Antoine's paper is published in PNAS with a insightful highlight in Nat Methods.
Nov '16: Jean-Bernard, Laura and Leon published their paper in Nature! <More news>

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Featured Publications

Isotropic angular reconstruction from 2D super-resolution images

We worked out a method to adapt cryo-EM reconstruction algorithms to obtain isotropic 3D structures from 2D super-resolution images

Salas, Le Gall, et al, PNAS (2017) [PDF]
Highlights in Nat Methods [PDF]

Molecular dissection of bacterial gliding

We deciphered the mechanism by which  Myxococcus Xhantus glide on surfaces using a revolutionary combination of advanced microscopies and microfluidics.​
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​ Faure, et al. Nature (2016)
[Blog] [Video]

TAD organization is not stochastic!

 We used microscopy to measure the absolute contact probabilities between genomic loci. See more here!
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Cattoni, Cardozo-Gizzi, Georgieva, et al, Nature Comm (2017)​​ [PDF]

Plasmid segregation super-resolved

We used super-resolution and multifocus microscopies to show that plasmids segregate through bacterial nucleoids by the action of ParA  and by relying on the host chromosome scaffold​
​Le Gall, et al. Nature Comm (2016)

3D localization microscopy over 4µm depth 

We combined multifocus microscopy with single-molecule localization to image cells at super-resolution over 4µm
Oudjedi, Biom. Optics Express (2016)

Bacterial chromosome structure

Condensin- and replication-mediated dynamic folding of a bacterial chromosome and its origin domain revealed by super-resolution imaging and Hi-C​

​Marbouty, et al. Mol Cell (2015)

Design of highly efficient multifocus gratings! 

Highly efficient multicolor multifocus microscopy by optimal design of diffraction binary gratings
​Hajj, et al., Scientific Reports (2017)

Assembly of bacterial partition systems

Stochastic Self-Assembly of ParB Proteins Builds the Bacterial DNA Segregation Apparatus

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Sanchez, et al., Cell Systems (2015)

Assembly and mechanism of a DNA pump

Recruitment, Assembly, and Molecular Architecture of the SpoIIIE Revealed by Superresolution Microscopy.
Fiche, et al., PLoS Biology (2013)

A complete list of publications, including chapters and articles not accessed by PubMed, can be found here.

Funders