Who we are
Welcome to Marcelo Nollmann's research group at the Center for Structural Biochemistry of the CNRS/INSERM
We develop single-molecule and advanced microscopy methodologies to understand the mechanisms underlying DNA organization in multi-cellular organisms.
Feb'19: congratulations to the team for the Hi-M paper being accepted in Mol Cell !
Jan'18: physics to understand living systems: interview by the Bettencourt Schueller Fondation.
Nov'17: we were awarded the Bettencourt-Schueller 'Coup d'Elan 2017' prize !
Sept'17: Diego, Andres and Mariya had their paper accepted in Nature Communications!
Sep '17: Our ERC consolidator grant started!
Aug'17: Desiree's and Antoine's paper is published in PNAS with a insightful highlight in Nat Methods.
Nov '16: Jean-Bernard, Laura and Leon published their paper in Nature! <More news>
Isotropic angular reconstruction from 2D super-resolution images
We worked out a method to adapt cryo-EM reconstruction algorithms to obtain isotropic 3D structures from 2D super-resolution images
Molecular dissection of bacterial gliding
TAD organization is not stochastic!
We used microscopy to measure the absolute contact probabilities between genomic loci. See more here!
Cattoni, Cardozo-Gizzi, Georgieva, et al, Nature Comm (2017) [PDF]
Plasmid segregation super-resolved
We used super-resolution and multifocus microscopies to show that plasmids segregate through bacterial nucleoids by the action of ParA and by relying on the host chromosome scaffold
Le Gall, et al. Nature Comm (2016)
3D localization microscopy over 4µm depth
We combined multifocus microscopy with single-molecule localization to image cells at super-resolution over 4µm
Oudjedi, Biom. Optics Express (2016)
Bacterial chromosome structure
Condensin- and replication-mediated dynamic folding of a bacterial chromosome and its origin domain revealed by super-resolution imaging and Hi-C
Marbouty, et al. Mol Cell (2015)
Design of highly efficient multifocus gratings!
Highly efficient multicolor multifocus microscopy by optimal design of diffraction binary gratings
Hajj, et al., Scientific Reports (2017)
Assembly of bacterial partition systems
Stochastic Self-Assembly of ParB Proteins Builds the Bacterial DNA Segregation Apparatus
Sanchez, et al., Cell Systems (2015)
Assembly and mechanism of a DNA pump
Recruitment, Assembly, and Molecular Architecture of the SpoIIIE Revealed by Superresolution Microscopy.
Fiche, et al., PLoS Biology (2013)
A complete list of publications, including chapters and articles not accessed by PubMed, can be found here.