Research projects

Chromatin structure and transcriptional regulation

We are interested in the investigation of chromatin structure and at the mechanisms involved in this organization. Our model systems are Drosophila, mice, human, and bacteria. To reach this objective, we develop multiplexed super-resolution imaging and other advanced microscopy methods, as well as gene editing and genome-wide approaches. Below you will find a description of our most recent studies:

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Molecular Motors

DNA motors use the energy of ATP hydrolysis to processively translocate DNA between cellular compartments or within different cells, and belong to the large and diverse AAA+ family of enzymes. AAA+ motors form multimeric rings in which ATP hydrolysis and mechanical work are closely coupled. In general, we are interested in understanding the larger network of genetic interactions affecting the process of DNA transport in vivo. In particular, we want to understand the general mechanisms governing translocation directionality, transduction of energy into movement, and complex assembly

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Single-molecule and super-resolution microscopies

Studying these problems requires the continued development of new technologies. In our lab, we concentrate in super-resolution, and single-molecule-based microscopies as well as in data analysis of complex datasets from microscopy or genome-wide sources.

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